A new one Research In spoke In the malaria parasite New Mutation that pregnant Women And in children Disease Increase resistance to the drug used to prevent, are already common. Malaria is caused by parasites (Plasmodium species) that feed on infected mosquitoes that enter the blood. London School of Hygiene and Tropical Medicine (LSHTM) co-author Taney Clarke said, “We need to understand requirement Is that Change how Work Do and malaria Eye As part of their programs Eye We do.“
Malaria each year Young children in sub-Saharan Africa account for about 435,000 people The death Causes. Despite the prolonged global response, the rise of drug resistant strains of parasitic species that cause malaria causes this Disease Efforts to control is being hampered. For example, sulfadoxine-pyrythaamine (SP), the first malaria at a time the treatment Was, but now its use pregnant Women And is used to prevent infection in children. Mutations in two genes in the parasite Plasmodium falciparum confer resistance to SP, but recently, resistance-related mutations were discovered in a third gene, pfgch1 (GTP cyclohydrolase I gene).
To understand the extent and spread of these new mutations, the researchers 29 The nations Analyzed genome sequences from 4,134 blood samples collected from where malaria is endemic. He has at least ten of pfgch1 Different Discovered versions that occur in about a quarter of samples from Southeast Asia, and in a third of samples from Africa, where stresses leading to mutations may increase.